LACHGAS FUNDAMENTALS EXPLAINED

The final proposed system of RBC vasodilation in the existence of nitrite is the reduction of nitrite to NO by Hb. Brooks 1st examined the nitrite Hb interaction in 1937 which work was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937; Doyle et al., 1981).